Bufa-20,22-dienolide,3,11,14-trihydroxy-12-oxo-, (3b,5b,11a)- - Names and Identifiers
Name | Arenobufagin
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Synonyms | Arenobufagin arenobufagin Arenobufogenin Arenobufagin, BR 3β,11α,14-Trihydroxy-12-oxo-5β-bufa-20,22-dienolide Bufa-20,22-dienolide,3,11,14-trihydroxy-12-oxo-, (3b,5b,11a)- Bufa-20,22-dienolide, 3,11,14-trihydroxy-12-oxo-, (3β,5β,11α)- (3beta,5beta,11alpha)-3,11,14-Trihydroxy-12-oxobufa-20,22-dienolide (3beta,5beta,8xi,9xi,11alpha)-3,11,14-trihydroxy-12-oxobufa-20,22-dienolide
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CAS | 464-74-4
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Bufa-20,22-dienolide,3,11,14-trihydroxy-12-oxo-, (3b,5b,11a)- - Physico-chemical Properties
Molecular Formula | C24H32O6
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Molar Mass | 416.51 |
Density | 1.349 |
Melting Point | 222-228℃ |
Boling Point | 637.2±55.0 °C(Predicted) |
Specific Rotation(α) | +56 (MeOH) |
Solubility | DMSO : 250 mg/mL (600.23 mM; Need ultrasonic);Ethanol : 10 mg/mL (24.01 mM; Need ultra |
Appearance | Powder |
pKa | 12.39±0.70(Predicted) |
Storage Condition | 2-8°C |
MDL | MFCD01740820 |
Bufa-20,22-dienolide,3,11,14-trihydroxy-12-oxo-, (3b,5b,11a)- - Reference
Reference Show more | 1. [IF=4.411] Yueting Cao et al."Chemical Profile and Multicomponent Quantitative Analysis for the Quality Evaluation of Toad Venom from Different Origins."Molecules. 2019 Jan;24(19):3595 |
Bufa-20,22-dienolide,3,11,14-trihydroxy-12-oxo-, (3b,5b,11a)- - Introduction
Arenobufagin is a toxin derived from the skin of the Shamus laevis, which exists in the form of white crystals. Its main ingredient is an alkaloid called tadpole protein.
Arenobufagin has a strong toxicity, can inhibit the function of the nervous system. It is lethal to a variety of animals and must be used with care. For humans, Arenobufagin is highly toxic and requires special care when used to avoid contact or inhalation.
In medical research, Arenobufagin has potential application in the treatment of inflammation and pain. However, due to its strong toxicity, research and application are limited.
The preparation method of Arenobufagin is relatively complicated. Generally, toxins need to be extracted from the skin of Xopus laevis, and pure Arenobufagin can only be obtained through a series of chemical treatment and purification processes.
When using Arenobufagin, safety procedures must be strictly observed. Exposure to or inhalation of Arenobufagin may cause toxic reactions that can cause breathing difficulties, neurological damage, and other serious health problems. Therefore, anyone using Arenobufagin must wear protective gloves, glasses and a mask, and operate in a well-ventilated environment. During the treatment, it is necessary to avoid contact with the skin of the toxin, while avoiding ingestion or inhalation.
Last Update:2024-04-09 21:04:16